openMorph

Curated list of open-access databases with human structural MRI data.

Feel free to make additions/updates via pull requests!

For an overview of benefits and considerations related to using open-access data for brain morphology research, see Madan (2017) Front Hum Neurosci [10.3389/fnhum.2017.00405].

ADNI

• Alzheimer’s Disease Neuroimaging Initiative
• http://adni.loni.usc.edu
  • older adults; dementia; longitudinal
  • T1, T2, DTI, ASL, rs-fMRI
• Mueller et al. (2005) Alzheimers Dement [10.1016/j.jalz.2005.06.003]
• Jack et al. (2008) J Magn Reson Imaging [10.1002/jmri.21049]

ABIDE

• Autism Brain Imaging Data Exchange
• http://fcon_1000.projects.nitrc.org/indi/abide/
  • N=1112
  • developmental; autism
  • T1, rs-fMRI
• Di Martino et al. (2014) Mol Psychiatry [10.1038/mp.2013.78]

ADHD-200

• http://fcon_1000.projects.nitrc.org/indi/adhd200/
  • N=973
  • developmental; ADHD
  • T1, rs-fMRI
• ADHD-200 Consortium (2012) Front Syst Neurosci [10.3389/fnsys.2012.00062]
• Bellec et al. (2017) NeuroImage [10.1016/j.neuroimage.2016.06.034]

Age-ility

• http://www.nitrc.org/projects/age-ility/
  • N=131
  • T1, dMRI, rs-fMRI, EEG
• Karayanidis et al. (2016) [10.1016/j.neuroimage.2015.04.047]

AIBL

• Australian Imaging, Biomarkers and Lifestyle
• http://www.aibl.csiro.au
  • N=1100
  • older adults; dementia; longitudinal
  • T1, PD, T2, DWI, FLAIR, SWI
• Ellis et al. (2009) Int Psychogeriatr [10.1017/S1041610209009405]

BRAINS

• Brain Images of Normal Subjects
• http://www.brainsimagebank.ac.uk
  • lifespan
• Job et al. (2017) NeuroImage [10.1016/j.neuroimage.2016.01.027]

CamCAN

• Cambridge Centre for Ageing and Neuroscience
• https://camcan-archive.mrc-cbu.cam.ac.uk/dataaccess/
  • N=653
  • lifespan; behavior
  • T1, T2, DTI, rs-fMRI, task fMRI
• Shafto et al. (2014) BMC Neurol [10.1186/s12883-014-0204-1]
• Taylor et al. (2017) NeuroImage [10.1016/j.neuroimage.2015.09.018]

CMI-HBN

• Child Mind Institute Healthy Brain Network
• http://fcon_1000.projects.nitrc.org/indi/cmi_healthy_brain_network/
  • N=664 (goal of 10,000)
  • developmental (aged 5-21)
  • T1, T2, DKI, rs-fMRI, EEG
• Alexander et al. (2017) bioRxiv [10.1101/149369]

COBRE

• Center for Biomedical Research Excellence
• http://cobre.mrn.org
• http://fcon_1000.projects.nitrc.org/indi/retro/cobre.html
  • N=72 patients, 75 healthy controls
  • schizophrenia; lifespan
  • T1; rs-fMRI

CoRR

• Consortium for Reliability and Reproducibility
• http://fcon_1000.projects.nitrc.org/indi/CoRR/html/
  • N=1629
  • young adults; test-retest
  • T1, rs-fMRI, some DTI
• Zuo et al. (2014) Sci Data [10.1038/sdata.2014.49]

DLBS

• Dallas Lifespan Brain Study
• http://fcon_1000.projects.nitrc.org/indi/retro/dlbs.html
  • N=315
  • lifespan; behavior
  • T1, PET

fBIRN

• Function Biomedical Informatics Research Network
• http://www.birncommunity.org
  • schizophrenia; test-retest; traveling subjects
• Keator et al. (2016) NeuroImage [10.1016/j.neuroimage.2015.09.003]

GSP

• Brain Genome Superstruct Project
• http://neuroinformatics.harvard.edu/gsp/
  • N=1570
  • young adults; test-retest; behavior
  • T1, rs-fMRI
• Holmes et al. (2015) Sci Data [10.1038/sdata.2015.31]

HCP

• Human Connectome Project
• http://humanconnectome.org
  • N=1200
  • young adults; behavior
  • T1, T2, rs-fMRI, task fMRI, Q-Ball
• Van Essen et al. (2013) NeuroImage [10.1016/j.neuroimage.2013.05.041]
• Glasser et al. (2016) Nat Neurosci [10.1038/nn.4361]

IXI

• Information eXtraction from Images
• http://brain-development.org/ixi-dataset/
  • lifespan
  • T1, T2, PD, MRA, DTI

Kirby 21

• http://www.nitrc.org/projects/multimodal
  • N=21
  • test-retest
  • T1, T1, DTI, FLAIR, ASL, VASO, rs-fMRI
• Landman et al. (2011) [10.1016/j.neuroimage.2010.11.047]

Maastrict 7T 700μm

• https://zenodo.org/record/1117858
  • T1w, PDw, T2*w images, n=5, age range 24-30, no medical condition
  • MP2RAGE (T1, UNI, INV1, INV2) and T2*w (Multi-echo 3D GRE, TE1/TE2/TE3/TE4 = 2.53/7.03/12.55/20.35 ms) images, n=4, age range 24-58, no medical condition
• Gulban et al. (2018) 10.1371/journal.pone.0198335

MASSIVE

• Multiple Acquisitions for Standardization of Structural Imaging Validation and Evaluation
• http://massive-data.org/index.html
  • N=1
  • multiple dMRI aquisitions
  • T1, T2, DWI, FLAIR
• Froeling et al. (2016) [10.1002/mrm.26259]

Mindboggle-101

• Mindboggle-101 data consist of three data sets:
  • N=101 individually labeled human brain surfaces and volumes
  • templates (unlabeled images combining the individual brains, used for registration)
  • atlases (anatomical labels combining the individual brains, used for labeling)
• http://www.mindboggle.info/data.html
• Data: https://osf.io/nhtur/; Labels: http://mindboggle.info/labels.html
• Klein & Tourville (2012) [10.3389/fnins.2012.00171]

MIRIAD

• Minimal Interval Resonance Imaging in Alzheimer's Disease
• https://www.ucl.ac.uk/drc/research/methods/miriad-scan-database
  • N=69
  • longitudinal
  • T1
• Malone et al. (2013) [10.1016/j.neuroimage.2012.12.044]

MPI-LMBB

• MPI-Leipzig Mind-Brain-Body
• https://openfmri.org/dataset/ds000221/
• https://www.nitrc.org/projects/mpilmbb/
  • N=320
  • behavior
  • T1, T2, DWI, rs-fRMI
• Mendes et al. (2017) [10.1101/164764]

MSC

• Midnight Scan Club
• https://openfmri.org/dataset/ds000224/
  • N=10
  • T1, T2, MRA, MRV, rs-fMRI, task fMRI
• Gordon et al. (2017) Neuron [10.1016/j.neuron.2017.07.011]

NACC

• National Alzheimer's Coordinating Center
• https://www.alz.washington.edu
  • lifespan; dementia; longitudinal
  • T1, T2, DTI, FLAIR
• Morris et al. (2006) [10.1097/01.wad.0000213865.09806.92]

NCANDA

• National Consortium on Alcohol and Neurodevelopment in Adolescence
• http://ncanda.org
• https://www.niaaa.nih.gov/research/major-initiatives/national-consortium-alcohol-and-neurodevelopment-adolescence#Data
  • N ~ 800
  • adolescence, alcohol, development, longitudinal
  • T1, DTI, rs-fMRI
• Brown et al. (2015) [10.15288/jsad.2015.76.895]

NKIRS

• Nathan Kline Institute - Rockland Sample
• http://fcon_1000.projects.nitrc.org/indi/enhanced/
  • N=683 (and counting)
  • developmental; lifespan; behavior
  • T1, DTI, rs-fMRI
• Nooner et al. (2012) [10.3389/fnins.2012.00152]

OASIS cross-sectional

• Open Access Series of Imaging Studies
• http://www.oasis-brains.org
  • N=416
  • lifespan; dementia; test-retest
  • T1 only
• Marcus et al. (2007) J Cogn Neurosci [10.1162/jocn.2007.19.9.1498]

OASIS longitudinal

• Open Access Series of Imaging Studies
• http://www.oasis-brains.org
  • N=150
  • older adults; longitudinal; dementia
  • T1 only
• Marcus et al. (2010) J Cogn Neurosci [10.1162/jocn.2009.21407]

OpenNeuro (former OpenfMRI)

• https://www.openneuro.org
  • 75 datasets (and counting)
  • 2600 subjects (and counting)
  • Please see individual dataset pages for details
• Poldrack & Gorgolewski (2017) NeuroImage [10.1016/j.neuroimage.2015.05.073]
• Poldrack et al. (2013) Front Neuroinform [10.3389/fninf.2013.00012]

PING

• Pediatric Imaging, Neurocognition, and Genetics
• http://pingstudy.ucsd.edu
  • N=1493
  • developmental; behavior
  • T1, T2, DTI, and rs-fMRI
• Jernigan et al. (2016) NeuroImage [10.1016/j.neuroimage.2015.04.057]

PNC

• Philadelphia Neurodevelopmental Cohort
• https://www.ncbi.nlm.nih.gov/projects/gap/cgi-bin/study.cgi?study_id=phs000607.v2.p2
  • N=1445
  • developmental
  • T1, DTI, ASL, task fMRI
• Satterthwaite et al. (2014) NeuroImage [10.1016/j.neuroimage.2013.07.064]
• Satterthwaite et al. (2016) NeuroImage [10.1016/j.neuroimage.2015.03.056]

PTBP

• Pediatric Template of Brain Perfusion
• https://figshare.com/articles/PTBP_Nifti/1190933
  • N=210
  • T1, dMRI, rs-fMRI, ASL
• Avants et al. (2015) [10.1038/sdata.2015.3]

SALD

• Southwest University Adult Lifespan Dataset
• http://fcon_1000.projects.nitrc.org/indi/retro/sald.html
  • N=494
  • lifespan
  • T1, rs-fMRI, task fMRI (subset)
• Wei et al. (2017) bioRxiv [10.1101/177279]

SchizConnect

• http://schizconnect.org
  • schizophrenia
  • T1, T2, DTI, rs-fMRI, task fMRI
• Wang et al. (2016) NeuroImage [10.1016/j.neuroimage.2015.06.065]

studyforrest

• http://studyforrest.org
  • N=20
  • T1, T2, dMRI, SWI, angiography
  • up to 10+ hours of 7T and 3T fMRI per subject (2h hollywood movie [audio and/or audio-visual], localizers, retinotopic mapping, with simult. cardiac/resp, partially with simult. eyetracking)
    • extensive movie stimulus annotations
  • musical education, visual acuity, visual sensitivity
• Hanke et al. (2014) [10.1038/sdata.2014.3]

T1-250μm

• http://hiresmri.ovgu.de
  • N=1
  • T1 (250 μm resolution)
• Lüsebrink et al. (2017) Sci Data [10.1038/sdata.2017.32]

TICV and Posterior Fossa Dataset

• https://www.nitrc.org/frs/download.php/9386/TICV_BC2atlases_20160823.zip
  • N = 20
  • T1w Scans with manual annotations of Intracranial Vault and Posterior Fossa + 133 more brain regions manually annotated
  • Orig MRI files distributed via neuromorphometrics.org
• Huo et al (2017) [10.1002/hbm.23432]

Test-Retest Reliability of Brain Volume Measurements

• https://openfmri.org/dataset/ds000239/
• https://figshare.com/collections/Test_Retest_Reliability_of_Brain_Volume_Measurements/929651
  • N=3, each scanned 40 times within 31 days
  • T1
• MacLaren et al. (2014) [10.1038/sdata.2014.37]

UK Biobank

• http://imaging.ukbiobank.ac.uk
  • N>10,000 (target=100,000)
  • lifespan; behavior; health
• Miller et al. (2016) [10.1038/nn.4393]
• Alfaro-Almagro et al. (2016) [10.1101/130385]

Download the Data

CoRR Download

The download_corr.ipynb jupyter notebook contains a script to webscrape the CoRR website and download the appropriate datasets.

Conda Environment

The conda_env.yml file contains the environment used to run the jupyter notebook. To create a conda environment from that file, execute conda env create -f conda_env.yml